A new article published in Tissue & Cell related that burn wounds have long-lasting devastating effects on the human body. Conventional therapeutic approaches are unable to completely heal burn wounds easily and effectively. Major drawbacks of these treatments include hypertrophic scarring, contracture and necrosis. 

The authors informed that regenerative potency of stem cells in burn wound healing fare better than the traditional treatment procedures. Thus, the use of multiple kinds of stem cells are gaining interest. Stem cells can be categorized based on – better and faster burn wound healing; decreased inflammation levels; less scar progression; and fibrosis on site. Evidence suggests that the use of stem cells on burn wounds–with or without scaffold—significantly improves healing. Moreover, homing of the stem cells at the wound site results in the re-epithelialization, angiogenesis, granulation, inhibition of apoptosis and regeneration of skin appendages together with reduced infection rate in the human studies. Moreover, the use of stem cells can effectively promote wound healing. Although more research is needed to determone the effectiveness of this treatment in patients with severe burn wounds. Source: Tissue & Cell. 2021 Mar 16;72:101527. doi: 10.1016/j.tice.2021.101527.